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Article

In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia

30 Sept 2009

Abstract excerpt

Clonal evolution and outgrowth of cellular variants with additional chromosomal abnormalities are major causes of disease progression in chronic lymphocytic leukemia (CLL). Because new DNA lesions occur during S phase, proliferating cells are at the core of this problem. In this study, we used in vivo deuterium ((2)H) labeling of CLL cells to better understand the phenotype of proliferating cells in 13 leukemic...

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Identifiers

PMID: 19789386
DOI: 10.1182/blood-2009-05-219634

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