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Article

CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells

8 Aug 2007

Abstract excerpt

Chronic lymphocytic leukemia (CLL) cells are thought to have diminished cell-cycling capacity, a view challenged by their phenotypic resemblance to activated human B lymphocytes. The present study addresses the cell-cycling status of CLL cells, focusing on those leukemic cells expressing CD38, a molecule involved in signaling and activation that also serves as a prognostic marker in this disease. CD38(+) and...

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Identifiers

PMID: 17684154
DOI: 10.1182/blood-2007-04-083832

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