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Article

CD38 and chronic lymphocytic leukemia: a decade later

16 Jul 2011

Abstract excerpt

This review highlights a decade of investigations into the role of CD38 in CLL. CD38 is accepted as a dependable marker of unfavorable prognosis and as an indicator of activation and proliferation of cells when tested. Leukemic clones with higher numbers of CD38(+) cells are more responsive to BCR signaling and are characterized by enhanced migration. In vitro activation through CD38 drives CLL proliferation and...

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PMID: 21765022
DOI: 10.1182/blood-2011-06-275610

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