Article
High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature.
European journal of haematology - 1 Jul 2012
Janssens Ann, Van Roy Nadine, Poppe Bruce, Noens Lucien, Philippé Jan, Speleman Frank, Offner Fritz
Abstract excerpt
BACKGROUND: We studied the relation of clonal evolution (CE) in Chronic B-lymphocytic leukemia (CLL) with prognostic factors and the correlation between CE and disease progression and overall survival. METHODS: With interphase fluorescence in situ hybridization (FISH) analysis, we looked for 11q22 deletion, 17p13 deletion, and trisomy 12. A second FISH was performed approximately 3 yr after the first one or...
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