Article
The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression.
Blood - 15 Feb 2003
Ghia Paolo, Guida Giuseppe, Stella Stefania, Gottardi Daniela, Geuna Massimo, Strola Giuliana, Scielzo Cristina, Caligaris-Cappio Federico
Abstract excerpt
Chronic lymphocytic leukemia (CLL) has a variable clinical course. CD38 expression and IgV(H) gene mutational status are independent predictors of prognosis, but their relationships and the CD38 cutoff level are unknown. Using cytofluorography, we analyzed CD38 in 148 patients, in 108 of whom we were able to evaluate IgV(H) mutations, make correlations with disease history, and assess cumulative survival. Three...
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