Article

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

2005-02-11

Abstract excerpt

Due to its relatively slow clinical progression, B cell chronic lymphocytic leukemia (B-CLL) is classically described as a disease of accumulation rather than proliferation. However, evidence for various forms of clonal evolution suggests that B-CLL clones may be more dynamic than previously assumed. We used a nonradioactive, stable isotopic labeling method to measure B-CLL cell kinetics in vivo. Nineteen patients...

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Literature Corpus work: 51095220-064c-5efa-ad69-a9dfbd59de1d
DOI: 10.1172/jci200523409

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