Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting.

Leukemia - 1 Feb 2015

Vaisitti T, Audrito V, Serra S, Buonincontri R, Sociali G, Mannino E, Pagnani A, Zucchetto A, Tissino E, Vitale C, Coscia M, Usai C, Pepper C, Gattei V, Bruzzone S, Deaglio S

Abstract excerpt

The ecto-enzyme CD38 is gaining momentum as a novel therapeutic target for patients with hematological malignancies, with several anti-CD38 monoclonal antibodies in clinical trials with promising results. In chronic lymphocytic leukemia (CLL) CD38 is a marker of unfavorable prognosis and a central factor in the pathogenetic network underlying the disease: activation of CD38 regulates genetic pathways involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Anthocyanins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flavonoids

Share to Glucosides

Share to Integrins

Share to Membrane Microdomains

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Receptors, Chemokine

Source

Identifiers

PMID: 24990614
DOI: 10.1038/leu.2014.207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting.PMID 24990614Read ↗

Role of CD38 Expression in Diagnosis and Pathogenesis of Chronic Lymphocytic Leukemia and Its Potential as Therapeutic TargetSemantic proximity Read ↗

CD38 and chronic lymphocytic leukemia: a decade laterSemantic proximity Read ↗

The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of AgingSemantic proximity Read ↗

CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia CellsSemantic proximity Read ↗

Highly purified CD38+ and CD38− sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal originSemantic proximity Read ↗

In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemiaSemantic proximity Read ↗

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.Semantic proximity Read ↗

CaMKK2 Identifies Biologically Aggressive Chronic Lymphocytic Leukemia and Regulates Leukemic Survival and Nurse-Like Cell SupportSemantic proximity Read ↗

p38 in chronic myelogenous leukemia: a target and a possible biomarker.Semantic proximity Read ↗

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive reviewSemantic proximity Read ↗

CD38 as a Therapeutic TargetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.