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POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA.

Nucleic acids research - 1 Dec 2009

Shakirov Eugene V, Song Xiangyu, Joseph Jessica A, Shippen Dorothy E

Abstract excerpt

Telomeric DNA terminates with a single-stranded 3' G-overhang that in vertebrates and fission yeast is bound by POT1 (Protection Of Telomeres). However, no in vitro telomeric DNA binding is associated with Arabidopsis POT1 paralogs. To further investigate POT1-DNA interaction in plants, we cloned POT1 genes from 11 plant species representing major branches of plant kingdom. Telomeric DNA binding was associated...

Topics

Algal Proteins
Amino Acid Sequence
Asparagus Plant
Binding Sites
Chlorophyta
DNA
Evolution, Molecular
Molecular Sequence Data
Mutation
Plant Proteins
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere

Telomere-Binding Proteins

Zea mays

Source

Open in PubMed Open full text

Identifiers

PMID: 19783822
DOI: 10.1093/nar/gkp785
PMCID: PMC2794166

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA.PMID 19783822Read ↗

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POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhangSemantic proximity Read ↗

Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

Pot1, the putative telomere end-binding protein in fission yeast and humans.Semantic proximity Read ↗

The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifsSemantic proximity Read ↗

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric ProteinsSemantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection.Semantic proximity Read ↗

Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

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