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Article

Modulation of expression of the hepatitis B virus surface antigen gene by the viral X-gene product.

Proceedings. Biological sciences - 23 Jul 1990

Rossner M T, Jackson R J, Murray K

Abstract excerpt

Human hepatoma cells (HepG2 and HUH7) transfected with a plasmid (pHBV1004) containing the transcription units for the major surface antigen (S) mRNA and the X mRNA of hepatitis B virus (HBV) secreted surface antigen (HBsAg) into the culture medium. A frameshift mutation in the X gene carried by pHBV1004 greatly reduced HBsAg production by cells transfected with an equivalent amount of the mutant (pHBV1004-B)....

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Identifiers

PMID: 1978336
DOI: 10.1098/rspb.1990.0065

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