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Article

Modulation of expression of the hepatitis B virus surface antigen gene by the viral X-gene product.

Proceedings. Biological sciences - 23 Jul 1990

Rossner M T, Jackson R J, Murray K

Abstract excerpt

Human hepatoma cells (HepG2 and HUH7) transfected with a plasmid (pHBV1004) containing the transcription units for the major surface antigen (S) mRNA and the X mRNA of hepatitis B virus (HBV) secreted surface antigen (HBsAg) into the culture medium. A frameshift mutation in the X gene carried by pHBV1004 greatly reduced HBsAg production by cells transfected with an equivalent amount of the mutant (pHBV1004-B)....

Topics

Gene Expression
Genes, Viral
Genetic Complementation Test
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Mutation
Plasmids
RNA, Messenger
Trans-Activators
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 1978336
DOI: 10.1098/rspb.1990.0065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1978336-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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