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Article

Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3.

Journal of hepatology - 1 Apr 2005

Yu Feng-Ling, Liu Hung-Jen, Lee Jeng-Woei, Liao Ming-Huei, Shih Wen-Ling

Abstract excerpt

BACKGROUND/AIMS: Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. How this regulation influences HCC is unclear. METHODS: Global gene expression in HBx-expressing and non-expressing hepatoma cells was analyzed using cDNA microarrays. RESULTS: Genes that were markedly up-...

Topics

Apoptosis
Carcinoma, Hepatocellular
Cell Line, Tumor
Cell Movement
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Neoplasms
Matrix Metalloproteinase 3
Oligonucleotide Array Sequence Analysis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Transcription Factor AP-1

Transcription, Genetic

Ultraviolet Rays

Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 15763339
DOI: 10.1016/j.jhep.2004.11.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15763339-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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