HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX.

doi:10.1038/sj.onc.1203209

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Article

HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX.

Oncogene - 9 Dec 1999

Doitsh G, Shaul Y

Abstract excerpt

Transcription of hepatitis B Virus (HBV), an important risk factor of hepatocellular carcinoma (HCC), is controlled by cellular transcription activators including some of the cellular signaling targets. Consequently, HBV transcription rate changes in response to the cellular physiological conditions. In this report we investigated HBV gene expression and the role of physiological levels of the viral X protein...

Topics

Antineoplastic Agents
Carcinoma, Hepatocellular
Cisplatin
DNA, Viral
DNA-Binding Proteins
Genes, Tumor Suppressor
Hepatitis B virus
Humans
Liver Neoplasms
Mutation
Nuclear Proteins
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress, Physiological

Suppression, Genetic

Trans-Activators

Transcription, Genetic

Tumor Cells, Cultured

Tumor Protein p73

Source

Open in PubMed

Identifiers

PMID: 10602509
DOI: 10.1038/sj.onc.1203209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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