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Article

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas.

International journal of cancer - 9 Feb 1999

Poussin K, Dienes H, Sirma H, Urban S, Beaugrand M, Franco D, Schirmacher P, Bréchot C, Paterlini Bréchot P

Abstract excerpt

To explore the role of hepatitis B virus (HBV) X protein in liver carcinogenesis, independently from its role in viral replication, we have analyzed X gene structure and expression in tumorous and non-tumorous tissues obtained from 9 hepatitis B surface antigen (HBsAg)-negative, HBV DNA-positive patients. HBV replication was undetectable in tumorous tissues. HBV X gene was truncated at its 3' end in 5 of 9...

Topics

Adolescent
Adult
Aged
Carcinoma, Hepatocellular
DNA, Viral
Female
Gene Expression
Genes, Viral
Humans
Liver Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Sequence Analysis, DNA

Trans-Activators

Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 9935147
DOI: 10.1002/(sici)1097-0215(19990209)80:4<497::aid-ijc3>3.0.co;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9935147-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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