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Article

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas.

International journal of cancer - 9 Feb 1999

Poussin K, Dienes H, Sirma H, Urban S, Beaugrand M, Franco D, Schirmacher P, Bréchot C, Paterlini Bréchot P

Abstract excerpt

To explore the role of hepatitis B virus (HBV) X protein in liver carcinogenesis, independently from its role in viral replication, we have analyzed X gene structure and expression in tumorous and non-tumorous tissues obtained from 9 hepatitis B surface antigen (HBsAg)-negative, HBV DNA-positive patients. HBV replication was undetectable in tumorous tissues. HBV X gene was truncated at its 3' end in 5 of 9...

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PMID: 9935147
DOI: 10.1002/(sici)1097-0215(19990209)80:4<497::aid-ijc3>3.0.co;2-8

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