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Article

Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells.

PloS one - 1 Jan 2016

Chan Wilson, Ismail Hodan, Mayaki Dominique, Sanchez Veronica, Tiedemann Kerstin, Davis Elaine C, Hussain Sabah N A

Abstract excerpt

BACKGROUND: Fibulin-5 is an extracellular matrix glycoprotein that plays critical roles in vasculogenesis and embryonic development. Deletion of Fibulin-5 in mice results in enhanced skin vascularization and upregulation of the angiogenesis factor angiopoietin-1 (Ang-1), suggesting that Fibulin-5 functions as an angiogenesis inhibitor. In this study, we investigate the inhibitory effects of Fibulin-5 on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27304216
DOI: 10.1371/journal.pone.0156994
PMCID: PMC4909301

Genes

DUSP5
EGR1
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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