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Article

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

1 Sept 2003

Abstract excerpt

Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Mutations of the bone morphogenetic protein (BMP) receptor type II (BMP-RII) gene have been implicated in patients with familial and sporadic PPH. The objective of this study was to elucidate the apoptotic effects of...

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PMID: 12740218
DOI: 10.1152/ajplung.00284.2002

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