Article
Effect of oxidation and mutation on the conformational dynamics and fibril assembly of amyloidogenic peptides derived from apolipoprotein C-II.
The journal of physical chemistry. B - 22 Oct 2009
Legge F S, Binger K J, Griffin M D W, Howlett G J, Scanlon D, Treutlein H, Yarovsky I
Abstract excerpt
The oxidation of methionine residues in proteins can inhibit the self-assembly of proteins to form amyloid fibrils. For human apolipoprotein (apo) C-II the oxidation of methionine at position 60 inhibits fibril formation by the mature protein and by the core peptides apoC-II(56-76) and apoC-II(60-70). To investigate the molecular nature of these effects, we carried out fully solvated, all-atom molecular dynamics...
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