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Article

Sequence dependence of amyloid fibril formation: insights from molecular dynamics simulations.

Journal of molecular biology - 10 Jun 2005

López de la Paz Manuela, de Mori Giacomo M S, Serrano Luis, Colombo Giorgio

Abstract excerpt

The clarification of the physico-chemical determinants underlying amyloid deposition is critical for our understanding of misfolding diseases. With this purpose we have performed a systematic all-atom molecular dynamics (MD) study of a series of single point mutants of the de novo designed amyloidogenic peptide STVIIE. Sixteen different 50ns long simulations using explicit solvent have been carried out starting...

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Identifiers

PMID: 15882870
DOI: 10.1016/j.jmb.2005.03.081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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