Article
Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.
Biochemistry - 28 Mar 2017
Todorova Nevena, Zlatic Courtney O, Mao Yu, Yarovsky Irene, Howlett Geoffrey J, Gooley Paul R, Griffin Michael D W
Abstract excerpt
The apolipoprotein family is structurally defined by amphipathic α-helical regions that interact with lipid surfaces. In the absence of lipid, human apolipoprotein (apo) C-II also forms well-defined amyloid fibrils with cross-β structure. Formation of this β-structure is accompanied by the burial of two charged residues, K30 and D69, that form an ion-pair within the amyloid fibril core. Molecular dynamics (MD)...
Topics
Join the communities discussing this publication.