Article
Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue.
Inorganic chemistry - 2 Nov 2009
Damante Chiara A, Osz Katalin, Nagy Zoltán, Pappalardo Giuseppe, Grasso Giulia, Impellizzeri Giuseppe, Rizzarelli Enrico, Sóvágó Imre
Abstract excerpt
Aggregation of the amyloid beta-peptide (Abeta) into insoluble fibrils is a key pathological event in Alzheimer's Disease (AD). There is now compelling evidence that metal binding to Abeta is involved in AD pathogenesis. The amino acid region 1-16 is widely considered as the metal binding domain of Abeta. In this work, we used a combined potentiometric, NMR, and electrospray ionization mass spectrometry (ESI-MS)...
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