Article

Redox reactivities of membrane-bound Amyloid-β-Cu complexes and their targeting by metallothionein-3

2025-06-17

Abstract excerpt

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ 1-40/42 ) in the central nervous system (CNS) and its aggregation in senile amyloid plaques. Copper coordination to Aβ triggers Aβ 1-40/42 aggregation and, in the presence of biological reducing agents, it promotes the catalytic generation of reactive oxygen species (ROS) via Fenton-type and Haber-Weiss reactions. Due to its a...

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Literature Corpus work: c31f618c-c363-5330-ba28-227957c0d3f3
DOI: 10.1101/2025.06.13.659328

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