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Article

A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H.

Angewandte Chemie (International ed. in English) - 18 Sept 2017

Polshakov Vladimir I, Mantsyzov Alexey B, Kozin Sergey A, Adzhubei Alexei A, Zhokhov Sergey S, van Beek Wouter, Kulikova Alexandra A, Indeykina Maria I, Mitkevich Vladimir A, Makarov Alexander A

Abstract excerpt

Zinc-induced oligomerization of amyloid-β peptide (Aβ) produces potentially pathogenic agents of Alzheimer's disease. Mutations and modifications in the metal binding domain 1-16 of Aβ peptide crucially affect its zinc-induced oligomerization by changing intermolecular zinc mediated interface. The 3D structure of this interface appearing in a range of Aβ species is a prospective drug target for disease modifying...

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Identifiers

PMID: 28570778
DOI: 10.1002/anie.201704615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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