Article

The Co(II) ion binds to the N-terminal region of amyloid-beta (Aβ) peptides and modulates Aβ aggregation

2026-04-01

Abstract excerpt

<title>Abstract</title> <p> Aggregating amyloid-β (Aβ) peptides play a central role in the neuropathology of Alzheimer’s disease (AD), the leading cause of dementia worldwide. In AD brains, Aβ peptides aggregate into insoluble amyloid plaques that contain elevated metal concentrations. AD patients furthermore often exhibit disrupted metal homeostasis. Despite extensive investigation, the metal aspect of AD remai...

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Literature Corpus work: ab95b2c0-e364-549a-8409-e73e8ef3881f
DOI: 10.21203/rs.3.rs-9246550/v1

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