Article

Dual-action peptide shuttles rescue Cu-amyloid-β-induced neurotoxicity and relocate Cu intracellularly

2024-09-08

Abstract excerpt

Alzheimer’s disease (AD) remains the most prevalent neurodegenerative disease characterized by intracellular neurofibrillary tangles of Tau protein and extracellular senile plaques build on Amyloid-β (Aβ) peptides. The latter result from an abnormal processing of Amyloid Precursor Protein (APP) leading to its accumulation in plaques. Ex vivo analyses of AD patients’ brains show an abnormally elevated concentratio...

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Literature Corpus work: d2f89051-5b14-55d8-a111-87b0f3c0ac4d
DOI: 10.1101/2024.09.04.611242

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