Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer's Amyloid-β with Taiwan (D7H) Mutation.

doi:10.3390/ijms241411241

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Article

Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer's Amyloid-β with Taiwan (D7H) Mutation.

International journal of molecular sciences - 8 Jul 2023

Kechko Olga I, Adzhubei Alexei A, Tolstova Anna P, Indeykina Maria I, Popov Igor A, Zhokhov Sergey S, Gnuchev Nikolay V, Mitkevich Vladimir A, Makarov Alexander A, Kozin Sergey A

Abstract excerpt

Amyloid-β (Aβ) is a peptide formed by 39-43 amino acids, heterogenous by the length of its C-terminus. Aβ constitutes a subnanomolar monomeric component of human biological fluids; however, in sporadic variants of Alzheimer's disease (AD), it forms soluble neurotoxic oligomers and accumulates as insoluble extracellular polymeric aggregates (amyloid plaques) in the brain tissues. The plaque formation is controlled...

Topics

Humans
Animals
Mice
Alzheimer Disease
Zinc
Taiwan
Plaque, Amyloid
Amyloid beta-Peptides
Protein Isoforms
Mutation
Ions

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Identifiers

PMID: 37511001
DOI: 10.3390/ijms241411241
PMCID: PMC10378775

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