Article
No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes.
PloS one - 25 Sept 2009
Gjesing Anette P, Sparsø Thomas, Borch-Johnsen Knut, Jørgensen Torben, Pedersen Oluf, Hansen Torben, Olsen Niels V
Abstract excerpt
BACKGROUND: Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well...
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