Article
Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2005
Bao Xuping, Mills Paul J, Rana Brinda K, Dimsdale Joel E, Schork Nicholas J, Smith Douglas W, Rao Fangwen, Milic Milos, O'Connor Daniel T, Ziegler Michael G
Abstract excerpt
Few studies have examined to what extent genetic variants of the beta2-adrenoceptor (ADRB2) are involved in the development of hypertension with age, although beta2-adrenergic receptor responsiveness declines in older subjects. To investigate this, 10 common single-nucleotide polymorphisms (SNPs) in the promoter and coding regions of the ADRB2 gene were genotyped in an unrelated population consisting of 2 ethnic...
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