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Article

Variations in the alpha2A-adrenergic receptor gene and their functional effects.

Clinical pharmacology and therapeutics - 1 Mar 2006

Kurnik Daniel, Muszkat Mordechai, Li Chun, Sofowora Gbenga G, Solus Joseph, Xie Hong-Guang, Harris Paul A, Jiang Lan, McMunn Chara, Ihrie Patrick, Dawson Elliott P, Williams Scott M, Wood Alastair J J, Stein C Michael

Abstract excerpt

BACKGROUND AND OBJECTIVES: The alpha2A-adrenergic receptor (ADRA2A) plays a central role in the regulation of systemic sympathetic activity and hence cardiovascular responses such as heart rate and blood pressure. The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants....

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Identifiers

PMID: 16513442
DOI: 10.1016/j.clpt.2005.10.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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