Article
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2006
Small Kersten M, Brown Kari M, Seman Carrie A, Theiss Cheryl T, Liggett Stephen B
Abstract excerpt
Alpha(2A)-adrenergic receptors (alpha(2A)AR) regulate multiple central nervous system, cardiovascular, and metabolic processes including neurotransmitter release, platelet aggregation, blood pressure, insulin secretion, and lipolysis. Complex diseases associated with alpha(2A)AR dysfunction display familial clustering, phenotypic heterogeneity, and interindividual variability in response to therapy targeted to...
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