Article
Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Dec 2009
Geretti Anna Maria, Fox Zoe V, Booth Clare L, Smith Colette J, Phillips Andrew N, Johnson Margaret, Li Jin-Fen, Heneine Walid, Johnson Jeffrey A
Abstract excerpt
BACKGROUND: There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART). METHODS: Patients started nevirapine or efavirenz with two or more nucleoside/nucleotide reverse transcriptase inhibitors in 1998-2007 without a prior resistance test at a median 1.0 (interquartile range, 0.0-3.4) year after diagnosis and...
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