Article
Low-frequency nevirapine resistance at multiple sites may predict treatment failure in infants on nevirapine-based treatment.
Journal of acquired immune deficiency syndromes (1999) - 1 Jul 2012
Lehman Dara A, Wamalwa Dalton C, McCoy Connor O, Matsen Frederick A, Langat Agnes, Chohan Bhavna H, Benki-Nugent Sarah, Custers-Allen Rebecca, Bushman Frederic D, John-Stewart Grace C, Overbaugh Julie
Abstract excerpt
BACKGROUND: Resistance commonly arises in infants exposed to single-dose nevirapine (sdNVP) for prevention of mother to child transmission. Although K103N and Y181C are common following sdNVP, multiple other mutations also confer NVP resistance. It remains unclear whether specific NVP resistance mutations or combinations of mutations predict virologic failure in infants when present at low frequencies before...
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