Article
Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitors.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2009
Varghese Vici, Shahriar Rajin, Rhee Soo-Yon, Liu Tommy, Simen Birgitte B, Egholm Michael, Hanczaruk Bozena, Blake Lisbeth A, Gharizadeh Baback, Babrzadeh Farbod, Bachmann Michael H, Fessel W Jeffrey, Shafer Robert W
Abstract excerpt
OBJECTIVES: K103N, the most common nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutation in patients with transmitted resistance and in patients receiving a failing NNRTI-containing regimen, is fully susceptible to the new NNRTI, etravirine. Therefore, we sought to determine how often NNRTI-resistant mutations other than K103N occur as minority variants in plasma samples for which standard...
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