Article
Enhanced surveillance of HIV-1 drug resistance in recently infected MSM in the UK.
The Journal of antimicrobial chemotherapy - 1 Jan 2017
Cunningham Emma, Chan Yuen-Ting, Aghaizu Adamma, Bibby David F, Murphy Gary, Tosswill Jennifer, Harris Ross J, Myers Richard, Field Nigel, Delpech Valerie, Cane Patricia A, Gill O Noel, Mbisa Jean L
Abstract excerpt
OBJECTIVES: To determine the prevalence of inferred low-frequency HIV-1 transmitted drug resistance (TDR) in MSM in the UK and its predicted effect on first-line therapy. METHODS: The HIV-1 pol gene was amplified from 442 newly diagnosed MSM identified as likely recently infected by serological avidity testing in 2011-13. The PCR products were sequenced by next-generation sequencing with a mutation frequency...
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