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Article

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

The Journal of clinical investigation - 1 Nov 2011

Pearson Helen B, Perez-Mancera Pedro A, Dow Lukas E, Ryan Andrew, Tennstedt Pierre, Bogani Debora, Elsum Imogen, Greenfield Andy, Tuveson David A, Simon Ronald, Humbert Patrick O

Abstract excerpt

Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at least three interacting protein complexes that have a critical role in establishing and maintaining epithelial polarity. In human colorectal, breast, and endometrial cancers, expression of the Scribble complex member SCRIB is...

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Identifiers

PMID: 21965329
DOI: 10.1172/JCI58509
PMCID: PMC3223862

Genes

SCRIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.PMID 21965329Read ↗

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