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Article

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo.

PloS one - 24 Sept 2009

Wyatt Haley D M, Tsang Allison R, Lobb Deirdre A, Beattie Tara L

Abstract excerpt

BACKGROUND: Telomerase is a reverse transcriptase that maintains the telomeres of linear chromosomes and preserves genomic integrity. The core components are a catalytic protein subunit, the telomerase reverse transcriptase (TERT), and an RNA subunit, the telomerase RNA (TR). Telomerase is unique in its ability to catalyze processive DNA synthesis, which is facilitated by telomere-specific DNA-binding domains in...

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Identifiers

PMID: 19777057
DOI: 10.1371/journal.pone.0007176
PMCID: PMC2744565

Genes

TERT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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