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Article

The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase.

Molecular and cellular biology - 1 Jan 2010

Drosopoulos William C, Prasad Vinayaka R

Abstract excerpt

The central hallmark of telomerases is repetitive copying of a short, defined sequence within its integral RNA subunit. We sought to identify structural determinants of this unique activity in the catalytic protein subunit telomerase reverse transcriptase (TERT) of telomerase. Residues within the highly conserved telomerase-specific T motif of human TERT were mutationally probed, leading to variant telomerases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19917726
DOI: 10.1128/MCB.00853-09
PMCID: PMC2798474

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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