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Article

Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase.

Molecular and cellular biology - 1 Jul 2000

Xia J, Peng Y, Mian I S, Lue N F

Abstract excerpt

Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. The key protein subunit of the telomerase complex, known as TERT, possesses reverse transcriptase-like motifs that presumably mediate catalysis. These motifs are located in the C-terminal region of the polypeptide. Hidden Markov model-based sequence analysis revealed in the...

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Identifiers

PMID: 10866675
DOI: 10.1128/MCB.20.14.5196-5207.2000
PMCID: PMC85968

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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