Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.

Nucleic acids research - 1 Jan 2007

Drosopoulos William C, Prasad Vinayaka R

Abstract excerpt

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, contains conserved motifs common to retroviral reverse transcriptases and telomerases. Within the C motif of hTERT is the Leu866-Val867-Asp868-Asp869 tetrapeptide that includes a catalytically essential aspartate dyad. Site-directed mutagenesis of Tyr183 and Met184 residues in HIV-1 RT, residues analogous to Leu866 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleotides

Share to Sequence Alignment

Share to Telomerase

Share to Templates, Genetic

Share to Thymine Nucleotides

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 17264120
DOI: 10.1093/nar/gkm002
PMCID: PMC1851649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.PMID 17264120Read ↗

New Human Immunodeficiency Virus, Type 1 Reverse Transcriptase (HIV-1 RT) Mutants with Increased Fidelity of DNA SynthesisSemantic proximity Read ↗

Human telomerase RNA template sequence is a determinant of telomere repeat extension rate.Semantic proximity Read ↗

Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.Semantic proximity Read ↗

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo.Semantic proximity Read ↗

The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase.Semantic proximity Read ↗

Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.Semantic proximity Read ↗

Differential Influence of Nucleoside Analog-resistance Mutations K65R and L74V on the Overall Mutation Rate and Error Specificity of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseSemantic proximity Read ↗

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.Semantic proximity Read ↗

Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Semantic proximity Read ↗

Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.