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Phage transcriptional regulator X (PtrX)-mediated augmentation of toxin production and virulence in <i>Clostridioides difficile</i> strain R20291

2023-08-25

Abstract excerpt

Clostridioides difficile is a Gram-positive, anaerobic, and spore-forming bacterial member of the human gut microbiome. The primary virulence factors of C. difficile are toxin A and toxin B. These toxins damage the cell cytoskeleton and cause various diseases, from diarrhea to severe pseudomembranous colitis. Evidence suggests that bacteriophages can regulate the expression of the pathogenic locus (PaLoc) genes o...

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Literature Corpus work
5d25376d-b78c-5295-8eee-b397e8d542fe
DOI
10.1101/2023.08.24.554564
Open publication

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Phage transcriptional regulator X (PtrX)-mediated augmentation of toxin production and virulence in <i>Clostridioides difficile</i> strain R20291DOI 10.1101/2023.08.24.554564
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