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Regulation of toxin synthesis in <i>Clostridium difficile</i> by an alternative RNA polymerase sigma factor

24 Apr 2001

Abstract excerpt

Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the severity of the disease, but the mechanism by which toxin synthesis is regulated is unknown. The...

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PMID: 11320220
DOI: 10.1073/pnas.101126598

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