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Article

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants.

Cancer research - 14 Jul 2023

Chachad Dhruv, Patel Lalit R, Recio Carlos Vera, Pourebrahim Rasoul, Whitley Elizabeth M, Wang Wenyi, Su Xiaoping, Xu An, Lee Dung-Fang, Lozano Guillermina

Abstract excerpt

Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function (GOF) activities, such as promoting increased metastatic incidence compared with p53 loss, often mediated by the interaction of mutant p53 with a set of transcription factors. These interactions are largely context...

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Identifiers

PMID: 37205631
DOI: 10.1158/0008-5472.CAN-22-3464
PMCID: PMC10524763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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