Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.

doi:10.1016/j.parkreldis.2009.08.011

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Article

Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.

Parkinsonism & related disorders - 1 Feb 2010

Keeling Brett H, Vilariño-Güell Carles, Soto-Ortolaza Alexandra I, Ross Owen A, Uitti Ryan J, Rajput Alex, Wszolek Zbigniew K, Farrer Matthew J

Abstract excerpt

A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Two recent studies reported that the threonine allele of this polymorphism might be a risk factor for Parkinson disease (PD) and essential tremor (ET) development. Although PD and ET are considered different entities,...

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Identifiers

PMID: 19773194
DOI: 10.1016/j.parkreldis.2009.08.011
PMCID: PMC2845175

Genes

HNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.PMID 19773194Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.Semantic proximity Read ↗

No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.Semantic proximity Read ↗

The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.Semantic proximity Read ↗

Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.Semantic proximity Read ↗

Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians.Semantic proximity Read ↗

Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism.Semantic proximity Read ↗

DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease.Semantic proximity Read ↗

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Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.Semantic proximity Read ↗

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