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Article

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.

Neurobiology of aging - 1 Apr 2012

Palada Vinko, Terzić Janoš, Mazzulli Joseph, Bwala Grace, Hagenah Johann, Peterlin Borut, Hung Albert Y, Klein Christine, Krainc Dimitri

Abstract excerpt

Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City,...

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Source

Identifiers

PMID: 21794955
DOI: 10.1016/j.neurobiolaging.2011.06.015

Genes

HNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.PMID 21794955Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.Semantic proximity Read ↗

No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.Semantic proximity Read ↗

Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.Semantic proximity Read ↗

Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.Semantic proximity Read ↗

The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.Semantic proximity Read ↗

Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.Semantic proximity Read ↗

Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians.Semantic proximity Read ↗

Histamine pharmacogenomics.Semantic proximity Read ↗

Genetic variability of histamine receptors in patients with Parkinson's disease.Semantic proximity Read ↗

Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis.Semantic proximity Read ↗

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