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Article

Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Mar 2017

Jiménez-Jiménez Félix Javier, García-Martín Elena, Alonso-Navarro Hortensia, Martínez Carmen, Zurdo Martín, Turpín-Fenoll Laura, Millán-Pascual Jorge, Adeva-Bartolomé Teresa, Cubo Esther, Navacerrada Francisco, Rojo-Sebastián Ana, Rubio Lluisa, Ortega-Cubero Sara, Pastor Pau, Calleja Marisol, Plaza-Nieto José Francisco, Pilo-de-la-Fuente Belén, Arroyo-Solera Margarita, García-Albea Esteban, Agúndez José A G

Abstract excerpt

A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson's disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT...

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Source

Identifiers

PMID: 27837280
DOI: 10.1007/s00702-016-1645-z

Genes

HNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.PMID 27837280Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.Semantic proximity Read ↗

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