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Article

Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.

PloS one - 1 Jan 2015

Yang Xinglong, Liu Chuanxin, Zhang Jinxiang, Han Hongying, Wang Xiuyan, Liu Zhoulin, Xu Yanming

Abstract excerpt

Parkinson's disease (PD) and schizophrenia (SCZ) are frequent central nervous disorders that have unclear etiologies but that show similarities in their pathogenesis. Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated...

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Source

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Identifiers

PMID: 25768024
DOI: 10.1371/journal.pone.0119692
PMCID: PMC4359088

Genes

HNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.PMID 25768024Read ↗

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.Semantic proximity Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.Semantic proximity Read ↗

Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.Semantic proximity Read ↗

The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.Semantic proximity Read ↗

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