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Article

The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.

Neuromolecular medicine - 1 Jan 2008

Ledesma Maria C, García-Martín Elena, Alonso-Navarro Hortensia, Martínez Carmen, Jiménez-Jiménez Félix Javier, Benito-León Julián, Puertas Inmaculada, Rubio Lluisa, López-Alburquerque Tomás, Agúndez José A G

Abstract excerpt

OBJECTIVE: We analyzed in patients with essential tremor (ET) the Thr105Ile polymorphism of the Histamine N-methyltransferase (HNMT) enzyme that is associated to Parkinson's disease (PD) risk. METHODS: Leukocytary DNA from 204 ET patients and a control group of 295 unrelated healthy individuals was studied for the nonsynonymous HNMT Thr105Ile polymorphism by using amplification-restriction analyses. RESULTS:...

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Source

Identifiers

PMID: 18543121
DOI: 10.1007/s12017-008-8040-3

Genes

HNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.PMID 18543121Read ↗

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Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.Semantic proximity Read ↗

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.Semantic proximity Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.Semantic proximity Read ↗

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Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations.Semantic proximity Read ↗

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