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Article

No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.

Neuroscience letters - 4 Feb 2011

Marasović-Šušnjara Ivana, Palada Vinko, Marinović-Terzić Ivana, Mimica Ninoslav, Marin Josipa, Muck-Seler Dorotea, Mustapić Maja, Presečki Paola, Pivac Nela, Folnegović-Šmalc Vera, Marinović-Ćurin Jasna, Terzić Janoš

Abstract excerpt

Several abnormalities, including lower histamine levels in brain, elevated serum histamine and degeneration of histaminergic neurons in tuberomammillary nucleus, were described in the histaminergic system of patients with Alzheimer's disease (AD). Histamine is a central neurotransmitter with several functions in brain including regulation of memory, cognition, locomotion, and is degraded in part by histamine...

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Source

Identifiers

PMID: 21138759
DOI: 10.1016/j.neulet.2010.11.078

Genes

HNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.PMID 21138759Read ↗

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Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.Semantic proximity Read ↗

Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians.Semantic proximity Read ↗

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The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.Semantic proximity Read ↗

The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.Semantic proximity Read ↗

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