Article
Accelerated evolution in the reactive centre regions of serine protease inhibitors.
Nature - 1 Jan 2000
Hill R E, Hastie N D
Abstract excerpt
The serine protease inhibitors (serpins) are a family of proteins that function to control the action of serine proteases in many diverse physiological processes. The functional region or reactive centre of these inhibitors is near the C-terminal end and is an exposed site that acts as a bait for...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Biological Evolution
- Genes
- Mice
- Mutation
- Protease Inhibitors
- Proteins
- RNA, Messenger
- Rats
- Selection, Genetic
- Serine Proteinase Inhibitors
- Serpins
- Trypsin Inhibitors