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Article

Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergence.

Journal of molecular evolution - 1 Feb 1994

Rheaume C, Goodwin R L, Latimer J J, Baumann H, Berger F G

Abstract excerpt

The organization and sequence of genes encoding the alpha 1-proteinase inhibitor (alpha 1PI), a major serine proteinase inhibitor of the mammalian bloodstream, have been compared in several species, including murine rodents (genus Mus). Analysis of gene copy number indicates that amplification of alpha 1PI genes occurred at some time during evolution of the Mus genus, leading to fixation of a family of about...

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PMID: 8169957
DOI: 10.1007/BF00166159
PMCID: PMC4729375

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