Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergence.

doi:10.1007/BF00166159

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Article

Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergence.

Journal of molecular evolution - 1 Feb 1994

Rheaume C, Goodwin R L, Latimer J J, Baumann H, Berger F G

Abstract excerpt

The organization and sequence of genes encoding the alpha 1-proteinase inhibitor (alpha 1PI), a major serine proteinase inhibitor of the mammalian bloodstream, have been compared in several species, including murine rodents (genus Mus). Analysis of gene copy number indicates that amplification of alpha 1PI genes occurred at some time during evolution of the Mus genus, leading to fixation of a family of about...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Cloning, Molecular
DNA Probes
Gene Amplification
Gene Library
Genetic Variation
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Muridae

RNA, Messenger

Sequence Alignment

Sequence Analysis, DNA

Species Specificity

alpha 1-Antitrypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 8169957
DOI: 10.1007/BF00166159
PMCID: PMC4729375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8169957-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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