Article
Patterns of divergence during evolution of alpha 1-proteinase inhibitors in mammals.
Molecular biology and evolution - 1 Feb 1996
Goodwin R L, Baumann H, Berger F G
Abstract excerpt
alpha 1-Proteinase inhibitor (alpha 1-PI), a member of the serine proteinase inhibitor superfamily, has a primary role in controlling neutrophil elastase activity within the mammalian circulation. Several studies have indicated that the reactive center region of alpha 1-PI, the amino acid sequence of which is critical to recognition of and binding to target proteinases, is highly divergent within and among...
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