Article
Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.
Molecular biology and evolution - 1 May 2002
Barbour Karen W, Goodwin Richard L, Guillonneau François, Wang Yanping, Baumann Heinz, Berger Franklin G
Abstract excerpt
Alpha(1)-proteinase inhibitor (alpha(1)-PI) is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Alpha(1)-PI, like most serpins, functions by covalent binding to, and inhibition of, target proteinases. The interaction between alpha(1)-PI and its target is directed by the so-called reactive center loop (RCL), an...
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