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Article

Molecular bases for hereditary cancer-prone diseases.

The Journal of dermatology - 1 Nov 1992

Tatsumi K, Tachibana A, Fujimori A

Abstract excerpt

Constitutional loss or inactivation of one copy of a tumor-suppressor gene, as exemplified by hereditary retinoblastoma, increases the propensity for malignancies by reducing the number of events necessary for the complete loss of the negative regulatory function. We developed a selectable mutation assay employing a human lymphoblastoid cell line (LCL) derived from a heterozygous carrier of 2,8-dihydroxyadenine...

Topics

Animals
Cell Transformation, Neoplastic
Disease Susceptibility
Genes, Tumor Suppressor
Humans
Mice
Mice, Nude
Mutation
Neoplasms
Proto-Oncogene Mas
Skin Diseases
Skin Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Xeroderma Pigmentosum

Source

Identifiers

PMID: 1293155
DOI: 10.1111/j.1346-8138.1992.tb03760.x

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1293155-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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