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Article

Molecular bases for hereditary cancer-prone diseases.

The Journal of dermatology - 1 Nov 1992

Tatsumi K, Tachibana A, Fujimori A

Abstract excerpt

Constitutional loss or inactivation of one copy of a tumor-suppressor gene, as exemplified by hereditary retinoblastoma, increases the propensity for malignancies by reducing the number of events necessary for the complete loss of the negative regulatory function. We developed a selectable mutation assay employing a human lymphoblastoid cell line (LCL) derived from a heterozygous carrier of 2,8-dihydroxyadenine...

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Source

Identifiers

PMID: 1293155
DOI: 10.1111/j.1346-8138.1992.tb03760.x

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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